Aktualności
Facebook
UMED logo kolorowe

Zakład Biologii i Botaniki
Farmaceutycznej

2025

  1. Grąbkowska R., Krzemińska M., Gaweda-Walerych K., Kiss KA., Pluta K., Grzegorczyk-Karolak I. Enhancement of rosmarinic acid production in hairy root cultures of Perovskia atriplicifolia Benth. International Journal of Molecular Sciences 2025, 26(7): 1–20.
  2. Ejsmont W., Kiss K. A., Grzegorczyk-Karolak I. Optimization of in vitro shoot culture parameters for enhanced biomass and rosmarinic acid production in Salvia atropatana. Molecules 2025, 30(12): 1–18.
  3. Grzegorczyk-Karolak I., Gawęda Walerych K., Ejsmont W., Owczarek-Januszkiewicz A., Olszewska M., Grąbkowska R., Krzemińska M. Polyphenol production and gene expression in sage shoot cultures exposed to light-emitting diodes. Journal of Photochemistry and Photobiology B-Biology 2025, 264: 1–10.
  4. Król A., Kokotkiewicz A., Królicka A., Hinc K., Badura A., Lorenc A., Marzec-Wróblewska U., Bucińsk A., Kuźma Ł., Luczkiewicz M. Adventitious and hairy root cultures of Salvia apiana as a source of rosmarinic acid. International Journal of Molecular Sciences 2025, 26(7): 1–24.
  5. Skała E., Olszewska M. A., Kicel A. The enhancement of biomass accumulation, caffeoylquinic acid derivative production, and antioxidant activity of Rhaponticum carthamoides transformed roots cultured in a nutrient sprinkle bioreactor. International Journal of Molecular Sciences 2025, 26(4): 1–16.
  6. Szymczyk P.; Majewska, M.; Nowak, J. Proteins and DNA sequences interacting with tanshinones and tanshinone derivatives. International Journal of Molecular Sciences 2025, 26, 848.
  7. Szymczyk P., Nowak J., Majewska M. The role of CRABS CLAW transcription factor in floral organ development in plants. International Journal of Molecular Sciences 2025, 26(19): 1–21.
  8. Weremczuk-Jeżyna I., Grzegorczyk-Karolak I. A comprehensive review of the phenolic compounds in Dracocephalum genus (Lamiaceae) related to traditional uses of the species and their biological activities. Molecules 2025, 30(9): 1–48.

2024

  1. Gomulski J., Grzegorczyk-Karolak I. Clerodendrum trichotomum thunberg – an ornamental shrub with medical properties. Molecules 2024, 29 (14): 1–24.
  2. Gomulski J., Krzemińska M., Jochymek M., Kiss AK., Grzegorczyk-Karolak I. The influence of basal medium on polyphenol accumulation in shoot cultures of Clerodendrum trichotomum and Clerodendrum colebrookianum. Molecules 2024, 29 (24): 1–16.
  3. Grzegorczyk-Karolak, I., Krzemińska M., Grąbkowska R., Gomulski J., Żekanowski C., Gaweda-Walerych K. Accumulation of polyphenols and associated gene expression in hairy roots of Salvia viridis exposed to methyl jasmonate. International Journal of Molecular Sciences 2024, 5 (2): 1–14.
  4. Grzegorczyk-Karolak I., Tabaka P., Weremczuk-Jeżyna I. Enhancing polyphenol yield in Salvia viridis L. shoot culture through liquid medium optimization and light spectrum manipulation. Plant Cell Tissue and Organ Culture 2024, 156: 1–13.
  5. Grzegorczyk-Karolak I., Ejsmont W., Kiss AK., Tabaka P., Starbała W., Krzemińska M. Improvement of bioactive polyphenol accumulation in callus of Salvia atropatana Bunge. Molecules 2024, 29 (11): 1–18.
  6. Kuźma Ł., Kiss AK., Pieszyński I., Mojsiejew D., Pękala J., Nowak J. Biomass and phenolic acid accumulation in Salvia austriaca hairy roots grown in temporary immersion and mist-trickling bioreactors. Applied Sciences-Basel 2024, 14(21): 1–10.
  7. Zgoda M. M., Nowak S., Marczyński Z., Kuźma Ł., Markowicz-Piasecka M., Skibska B. Solubilizacja micelarna cholesterolu przez wodne roztwory ginsenozydów zawarte w ekstrakcie z żeń-szenia prawdziwego. Polish Journal of Cosmetology 27(2): 97–105.
  8. Skała E., Olszewska M., Tabaka P., Kicel A. Light-emitting diodes and liquid system affect the caffeoylquinic acid derivative and flavonoid production and shoot growth of Rhaponticum carthamoides (Willd.) Iljin, Molecules 2024, 29 (9): 1–21.
  9. Szymczyk P., Majewska M., Plant synthetic promoters. Applied Sciences-Basel 2024, 14 (11): 1–29.
  10. Weremczuk-Jeżyna I., Gomulski J., Kiss AK., Grzegorczyk-Karolak I.  Effect of Ag+ and Cd2+ elicitation on polyphenol production in shoot culture of Dracocephalum ruyschiana L. Molecules 2024, 29(22): 1–14.

2023

  1. Grzegorczyk-Karolak I., Krzemińska M., Kiss, AK., Owczarek-Januszkiewicz A., & Olszewska M. A. Role of phytohormones in biomass and polyphenol accumulation in Salvia bulleyana in vitro culture. Biomolecules 2023, 13(2), 227.
  2. Krzemińska M., Hnatuszko-Konka K., Weremczuk-Jeżyna I., Owczarek Januszkiewicz A., Ejsmont W., Olszewska M. A., & Grzegorczyk-Karolak I. Effect of light conditions on polyphenol production in transformed shoot culture of Salvia bulleyana Diels. Molecules 2023, 28(12): 4603.
  3. Sykłowska-Baranek K., Gaweł M., Kuźma Ł., Wileńska B., Kawka M., Jeziorek M., … Pietrosiuk A. Rindera graeca (A. DC.) Boiss. & Heldr.(Boraginaceae) In vitro cultures targeting lithospermic acid B and rosmarinic acid production. Molecules 2023, 28(12): 4880.
  4. Skała E., Szopa A. Dipsacus and Scabiosa species – The source of specialized metabolites with high biological relevance: a review. Molecules 2023, 28(9): 3754.
  5. Motyka S., Skała E., Ekiert H., & Szopa A. Health-promoting approaches of the use of chia seeds. Journal of Functional Foods 2023, 103: 105480.
  6. Szymczyk P. Closely-spaced repetitions of CAMTA trans-factor binding sites in promoters of model plant MEP pathway genes. Applied Sciences 2023, 13(17): 9680.
  7. Szymczyk P., Kuźma Ł., Jeleń A., Balcerczak E. and Majewska M.  Isolation of Salvia miltiorrhiza Kaurene Synthase-Like (KSL) genep and its regulation by ethephon and yeast extract. Genes 2023, 14(1)1: 1–23.
  8. Czarnecka K., Girek M., Kręcisz P., Skibiński R., Łątka K., … Szymczyk P., … Szymański, P. New cyclopentaquinoline and 3, 5-dichlorobenzoic acid hybrids with neuroprotection against oxidative stress for the treatment of alzheimer’s disease. Journal of Enzyme Inhibition and Medicinal Chemistry 2023, 38(1): 2158822.
  9. Weremczuk-Jeżyna I., Lebelt L., Piotrowska D., Gonciarz W., Chmiela M., Grzegorczyk-Karolak I. The optimization growth of Dracocephalum forrestii in RITA® bioreactor, and preliminary screening of the biological activity of the polyphenol rich extract. Acta Scientiarum Polonorum Hortorum Cultus 2023, 22(2): 45–59.
  10. Weremczuk-Jeżyna I., Gonciarz W., & Grzegorczyk-Karolak I. Antioxidant and anti-inflammatory activities of phenolic acid-rich extract from hairy roots of Dracocephalum moldavica. Molecules 2023, 28(19): 6759.

2022

  1. Grzegorczyk-Karolak I., Staniewska P., Lebelt L., Piotrowska DG. Optimization of cultivation conditions of Salvia viridis L. shoots in the Plantform bioreactor to increase polyphenol production. Plant Cell Tissue Organ Cult 2022, 149: 269–280.
  2. Grzegorczyk-Karolak I., Zglińska-Pietrzak A., Weremczuk-Jeżyna I., Kałucka S. Evaluation of patient experiences regarding pharmacist-administrated vaccination and attitude towards future additional pharmacy services in Poland. Vaccines 2022, 10: 1479.
  3. Kałucka S., Kusideł E., Grzegorczyk-Karolak I. A retrospective cross-sectional study on the risk of getting sick with COVID-19, the course of the disease, and the impact of the national vaccination program against SARS-CoV-2 on vaccination among health professionals in Poland. IJERPH 2022, 19(12): 7231.
  4. Kałucka S., Kusideł E., Głowacka A., Oczoś P., Grzegorczyk-Karolak I. Pre-vaccination stress, post-vaccination adverse reactions, and attitudes towards vaccination after receiving the COVID-19 vaccine among Health Care Workers. Vaccines 2022, 10: 401.
  5. Krzemińska M., Owczarek A., Olszewska MA., Grzegorczyk-Karolak I. In vitro strategy for the enhancement of the production of bioactive polyphenols in transformed roots of Salvia bulleyana. IJMS 2022, 23(14): 7771.
  6. Krzemińska M., Owczarek A., Gonciarz W., Chmiela M., Olszewska MA., Grzegorczyk-Karolak I. The antioxidant, cytotoxic and antimicrobial potential of phenolic acids enriched extract of elicited hairy roots of Salvia bulleyana. Molecules 2022, 27(3): 992.
  7. Kuźma Ł., Gomulski J. Biologically active diterpenoids in the Clerodendrum genus – a review. IJMS 2022, 23(19): 11001.
  8. Nowak J., Kiss AK., Wambebe C., Katuura E., Kuźma Ł. Phytochemical analysis of polyphenols in leaf extract from Vernonia amygdalina delile plant growing in Uganda. Applied Science 2022, 12: 912.
  1. Pietrosiuk A., Budzianowska A., Budzianowski J., Ekiert H., Jeziorek M., Kawiak A., Kuźma L., … Zielińska S. Polish achievements in bioactive compound production from in vitro plant cultures. Acta Societ Bot Polon 2022, 91.
  2. Majewska M., Szymczyk P., Gomulski J., Jeleń A., Grąbkowska R., Balcerczak E., Kuźma Ł. The expression profiles of the Salvia miltiorrhiza 3-hydroxy-3-methylglutaryl-coenzyme A reductase 4 gene and its influence on the biosynthesis of tanshinones. Molecules 2022, 27(14): 4354.
  3. Skała E., Olszewska MA., Makowczyńska J., & Kicel A. Effect of sucrose concentration on Rhaponticum carthamoides (Willd.) Iljin transformed root biomass, caffeoylquinic acid derivative, and flavonoid production. IJMS 2022, 23(22): 13848.
  4. Szymczyk P., Szymańska G., Kuźma Ł., Jeleń A., Balcerczak E. Methyl Jasmonate activates the 2C methyl-D-erithrytol 2,4-cyclodiphosphate synthase gene and stimulates tanshinone accumulation in Salvia miltiorrhiza solid callus cultures. Molecules 2022, 27: 1–21.
  5. Majewska M., Kuźma Ł., Szymczyk P. Isolation and comprehensive in silico characterisation of a new 3-hydroxy-3-methylglutaryl-coenzyme A reductase 4 (HMGR4) gene promoter from Salvia miltiorrhiza: comparative analyses of plant HMGR promoters. Plants 2022, 11(14): 1861.
  6. Szymczyk P., Szymańska G., Majewska M., Weremczuk-Jeżyna I., Kołodziejczyk M., Czarnecka K., Szymański P., Kochan E. Homology modelling and docking studies of strictosidine β-D-glucosidase from Madagascar periwinkle (Catharanthus roseus bunge). International Journal of Bioinformatics Research and Applications 2022, 18(3): 234–269.
  7. Szymczyk P., Kuźma Ł., Jeleń A., Balcerczak E., & Majewska M. Isolation of Salvia miltiorrhiza kaurene synthase-like (KSL) gene promoter and its regulation by ethephon and yeast extract. Genes 2022, 14(1): 54.
  8. Weremczuk-Jeżyna I., Hnatuszko-Konka K., Lebelt L., Piotrowska D. G., & Grzegorczyk-Karolak I. The effect of the stress-signalling sediator triacontanol on biochemical and physiological modifications in Dracocephalum forrestii culture. IJMS 2022, 23(23): 15147.

2021

  1. Grzegorczyk-Karolak I., Hnatuszko-Konka K., Wojciechowska M., Olszewska M., Owczarek A. Cytokinin-based tissue cultures for stable medicinal plant production: regeneration and phytochemical profiling of Salvia bulleyana shoots. Biomolecules 2021, 11: 1513.
  2. Hnatuszko-Konka K., Gerszberg A., Weremczuk-Jeżyna I., Grzegorczyk-Karolak I. Cytokinin signaling and de novo shoot organogenesis. Genes 2021, 12(2): 265.
  3. Kałucka S., Grzegorczyk-Karolak I. Barriers associated with the uptake ratio of seasonal flu vaccine and ways to improve influenza vaccination coverage among Polish young health care workers. Vaccines 2021, 9: 1–13.
  4. Kałucka S., Głowacka A., Dziankowska-Zaborszczyk E., Grzegorczyk-Karolak I. Knowledge, beliefs and attitudes towards the influenza vaccine among future healthcare workers in Poland. IJERPH 2021, 18(4): 2105.
  5. Piątczak E., Owczarek A., Lisiecki Gonciarz W., Kozłowska W., Szemraj M., Chmiela M., Kiss AK., Olszewska MA., Grzegorczyk-Karolak I. Identification and quantification of phenolic compounds in Salvia cadmica boiss and their biological potential. Ind Crops Prod 2021, 160: 1–9.
  6. Nowak J., Kiss AK., Wambebe C., Katuura E., Kuźma Ł. Tentative qualitative and quantitative analysis of phenolic compounds in leaf extract from Carica papaya Linn. plant growing in Uganda. Herba Polonica 2021, 67: 1–9.
  7. Makowczyńska J., Kalemba D., Skała E. Establishment of Codonopsis pilosula (Franch.) Nannf. transformed roots, influence of the culture conditions on root growth and production of essential oil. Ind. Crops Prod. 2021, 165: 113446.
  8. Szymczyk P., Szymańska G., Kochan E., Szemraj J., Grąbkowska R. Elicitation of solid callus cultures of Salvia miltiorrhiza bunge with salicylic acid and a synthetic auxin (1- naphthaleneacetic acid). Plant Cell Tissue and Organ Culture 2021, 147: 491–502.
  9. Weremczuk-Jeżyna I., Hantuszko –Konka K., Lebelt L., Grzegorczyk-Karolak I. The protective function and modification of secondary metabolite accumulation in response to light stress in Dracocephalum forrestii shoots. IJMS 2021, 22(15): 7965.
  10. Weremczuk-Jeżyna I., Kuźma Ł., Grzegorczyk-Karolak I. The effect of different light treatments on morphogenesis, phenolic compound accumulation and antioxidant potential of Dracocephalum forrestii transformed shoots cultured in vitro. Journal of Photochemistry and Photobiology B-Biology 2021, 224: 1–9.